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American Society of Microbiology ABMM Sample Questions:
1. An immunocompromised patient develops a disseminated fungal infection. Tissue biopsy reveals small (2-4
µm) yeast cells within macrophages. The patient has a history of living in the Ohio and Mississippi River valleys. The MOST likely causative agent is:
A) Blastomyces dermatitidis
B) Penicillium marneffei
C) Paracoccidioides brasiliensis
D) Histoplasma capsulatum
2. The primary mechanism of action of aminoglycoside antibiotics, such as gentamicin, involves:
A) Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins
B) Inhibition of bacterial DNA gyrase and topoisomerase IV
C) Disruption of bacterial cell membrane integrity
D) Inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit
3. A traveler returning from a tropical region presents with fever, chills, and jaundice. Peripheral blood smear reveals the presence of ring-shaped parasites within erythrocytes. Further laboratory testing shows a positive result for Plasmodium falciparum histidine-rich protein 2 (HRP2). The MOST appropriate treatment for this patient is:
A) Primaquine and a blood schizonticide (e.g., artemisinin-based combination therapy)
B) Metronidazole
C) Mebendazole
D) Amphotericin B
4. The direct fluorescent antibody (DFA) test is commonly used for the rapid detection of which respiratory pathogen directly from nasopharyngeal specimens?
A) Bordetella pertussis
B) Mycoplasma pneumoniae
C) Legionella pneumophila (serogroup 1 in sputum)
D) Influenza virus
5. A fungal isolate grown from a blood culture at 37°C shows budding yeast cells. When subcultured to cornmeal agar with Tween 80 and incubated at 25°C, it produces pseudohyphae and terminal chlamydospores.
Growth on CHROMagar Candida yields green colonies. This organism is most likely:
A) Candida glabrata
B) Candida albicans
C) Cryptococcus neoformans
D) Candida parapsilosis
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: D | Question # 3 Answer: A | Question # 4 Answer: A | Question # 5 Answer: B |
By Cecilia
